Cai W, et al. - Researchers investigated the efficacy of four-dimensional (4D) strain echocardiography in predicting major adverse cardiovascular events (MACE) in ST-elevation acute myocardial infarction (STEMI) patients who underwent successful primary coronary interven tion (PCI). Anterior MI, significantly decreased 2D left ventricular ejection fraction (2DLVEF) and 4DLVEF, as well as an overtly compromised 4D strain parameters were more likely to be seen among subjects with MACE vs in those without MACE. 4D strain echocardiography, compared with conventional 2D echocardiography, especially global area strain (GAS), provided a superior risk stratification in STEMI patients after successful primary PCI.