Zhu B, Yan L, Ren H, et al. - In acute ischemic stroke (CIS) treated with intravenous thrombolytic therapy (ITT), an effective prediction of the occurrence of hemorrhagic transformation (HT) post-therapy is enabled by Apelin and Vaspin as independent protective factors of HT, and thus they have a high clinical application value.

• A study of 109 CIS patients treated with intravenous thrombolysis (IT); 48 patients who had HT post-therapy were assigned to the research group and the other 61 without HT were assigned to the control group.

• A sensitivity of 77.08% and a specificity of 73.77% for predicting HT post- thrombolytic therapy (all ) was achieved with the joint detection of Apelin and Vaspin.

• Logistic analysis revealed interleukin-1β, IL-6, and malondialdehyde as independent risk factors for HT in CIS post- IT, while independent protective factors included Apelin, Vaspin, and superoxide dismutase.

• Follow-up results showed that Apelin and Vaspin had excellent value in predicting the death of patients with both CIS and HT, and a higher risk of death was indicated by their lower levels (all).