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Predictive score for in-hospital mortality of myasthenic crisis: A retrospective Chinese Cohort Study

European Neurology Nov 07, 2019

Lv Z, Zhong H, Huan X, et al. - Since myasthenic crisis (MC) is a life-threatening condition usually occurred in myasthenia gravis patients, researchers created a scoring system to assess the probability for in-hospital death in MC patients on the basis of a retrospective case series review. From January 2014 to December 2018, 78 MC patients who were hospitalized were retrospectively reviewed. Clinical and laboratory data involving 17 variables were examined univariately. In the MC cohort, the overall in-hospital mortality was 11.5% (9/78). Five clinical variables were found to be associated with in-hospital mortality including Myasthenia Gravis Foundation of America classification at onset, septic shock, thymoma classification, cardiac arrest, and the lowest serum albumin. The final regression was entered by three additional variables, and internal validation showed that the area under the curve was 0.919. To predict the in-hospital mortality, a scoring system with full credit of 7 points was generated. Based on a retrospective review of MC patients to predict in-hospital mortality, a 7-point scoring model was established.
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