Majzoub A, Arafa M, Khalafalla K, et al. - Via performing retrospective chart review of a total of 297 patients with nonobstructive azoospermia, researchers here examined predictors of successful sperm retrieval (SR) and sought to determine potentially suitable candidates for testicular sperm aspiration (TESA), a more straightforward, less traumatic, and less costly procedure than open surgical SR methods. Clinical evaluation of all patients was performed prior to performing a staged SR procedure, starting with TESA and proceeding to microsurgical testicular sperm extraction (microTESE). Overall, 23.6% of patients undergoing TESA had a positive SR. LASSO regression analysis suggested average testis size and serum follicle-stimulating hormone (FSH) level as the significant predictors of positive SR. A TESA-positive SR of 43% was reported for patients presenting with an average testis size > 7.75 mL and serum FSH level < 8.5 IU/L. Per these observations, TESA appears to be a suitable alternative to microTESE in selected nonobstructive azoospermia patients presenting with an average testis size > 7.75 mL and serum FSH level < 8.5 IU/L.