Kapsogeorgou EK, et al. - Researchers report a new biomarker, the miR200b-5p micro-RNA, for predicting lymphomagenesis in Sjögren syndrome (SS). For the differentiation of SS patients who have non-Hodgkin lymphomas (NHL) from those who do not have NHL, high specificity and sensitivity were seemed to be yielded by low levels of this microRNA in the minor salivary glands. Compared with the earlier published multifactorial models, a higher predictive value for independently predicting NHL development was demonstrated by miR200b-5p, being expressed years prior to the clinical onset of NHL. Furthermore, miR200b-5p may play a role in the monitoring of therapeutic response. Therefore, it affords a powerful candidate for the detection and follow-up of patients at risk.