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Predictive factors of survival in a surgical series of metastatic epidural spinal cord compression and complete external validation of 8 multivariate models of survival in a prospective North American multicenter study

Cancer Jul 11, 2018

Nater A, et al. - In surgically treated patients with metastatic epidural spinal cord compression (MESCC), researchers investigated preoperative predictors of survival and their association with eight prognostic models. They also carried out the first full external validation of these models in accordance with the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) statement. They identified that preoperative predictors of longer survival included the primary tumor type (breast, prostate, or thyroid), an absence of organ metastasis, and a lower degree of physical disability. These results were in keeping with current models. Poor calibration, particularly for long-term survivors, but possibly helpful discrimination was noted in the full external validation of 8 prognostic scoring systems or model of survival in surgical MESCC patients.

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