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Predictive factors for concomitant pulmonary arterial hypertension at diagnosis of systemic lupus erythematosus in a Chinese population

International Journal of Rheumatic Diseases Nov 24, 2021

Pan Y, Sun Y, He L, et al. - In patients suffering from systemic lupus erythematosus (SLE), the predictive factors for pulmonary arterial hypertension (PAH) include interstitial pneumonitis, myocardial damage, and high immunoglobin G (IgG).

  • This is a chart review of 408 SLE patients: 34 patients in the SLE/PAH+ group and 374 patients in the SLE/PAH− group.

  • PAH prevalence was 8.3%, and the SLE/PAH+ group showed higher occurrences of interstitial pneumonitis, polyserositis and myocardial damage and lower occurrence of anti-double-stranded DNA and anti-ribosomal RNA protein antibodies.

  • In the SLE/PAH+ group, there were higher positive rates of anti-Sjögren’s syndrome antigen A (anti-SSA)/Ro52 antibodies and anti-SSB antibodies, and higher were C-reactive protein and IgG.

  • No differences were found in ejection fraction and SLE disease activity index between the 2 groups.

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