Lv H, Liu PQ, Xiang R, et al. - Considering that nasal nitric oxide (nNO) is an established biomarker of eosinophilic inflammation in the upper airway, however, the usefulness of nNO assessment in the upper airway remains controversial, researchers sought to compare the use of other clinical parameters with nNO to prediagnose patients with eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) from Central China. Seventy patients with CRSwNP undergoing endoscopic sinus surgery and 30 healthy individuals were recruited from June 2019 to December 2019. Twenty-four patients with eCRSwNP and 46 with noneosinophilic CRSwNP (non-eCRSwNP) were recruited. In patients with eCRSwNP, nNO levels were significantly higher compared with those in patients with non-eCRSwNP. Blood eosinophil percentages and counts, total IgE, and CT-derived ethmoid sinus and maxillary sinus ratio (E/M ratio) were all significantly higher compared with those in non-eCRSwNP patients. Overall, the authors concluded that nNO measurement is useful for diagnosing eCRSwNP early.