Zhang F, Wang F, Chen C, et al. - In view of the reports documenting Helicobacter pylori (H. pylori) infection as a risk factor for aggravating gastric mucosal atrophy, researchers sought for biomarkers predictive of progression risk in chronic atrophic gastritis (CAG) with H. pylori. From the Gene Expression Omnibus, GSE27411 was downloaded. They analyzed H. pylori-infected samples without CAG and H. pylori-infected CAG samples for differentially expressed genes (DEGs). and identified a total of 303 upregulated and 26 downregulated DEGs. Further, they performed Gene Ontology and pathway enrichment analyses, followed by protein-protein interaction network construction. They identified the highest degrees in protein–protein interaction network for cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4). Findings suggest a possible correlation of the expression of CYP3A4 with the potential carcinogenic transformation of CAG to GC. Therefore, they suggest a possible value of CYP3A4 as biomarkers to predict the progression of CAG and poor prognosis of gastric cancer.