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Prediction of postinfectious bronchiolitis obliterans prognosis in children

Pediatric Pulmonology Apr 14, 2021

Jung JH, Kim GE, Min IK, et al. - In this study with 47 postinfectious bronchiolitis obliterans (PIBO) patients who had spirometry and impulse oscillometry and were observed for at least 1 year, researchers assessed the prognostic factors for PIBO using the baseline clinical features of patients and developed a prediction model for ascertaining the prognoses of PIBO patients using the detected parameters. Poor prognosis was defined as the presence of at least one of the following: persistent respiratory symptoms for more than 1 year, two or more instances of hospitalizations because of respiratory symptoms, or more than one intensive care unit admission. A nomogram for predicting prognoses was built using post‐bronchodilator forced expiratory volume in the first second and inflammatory bronchiolitis on chest computed tomography. An area under the curve of 84.6% was reported for this nomogram. Findings revealed that poor prognoses were experienced by PIBO patients with lower pulmonary function values and more findings of inflammatory bronchiolitis on initial examination. The nomogram proposed herein is readily applicable and can be used at the time of diagnosis.

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