Dieckmeyer M, Rayudu NM, Yeung LY, et al. - A case-control study was designed to explore different quantitative parameters derived from routine multi-detector computed tomography (MDCT) scans with respect to their ability to predict incident osteoporotic vertebral fractures of the thoracolumbar spine. Researchers enrolled a total of 16 patients who received baseline and follow-up contrast-enhanced MDCT and were diagnosed with an incident osteoporotic vertebral fracture at follow-up, and 16 age-, gender-, and follow-up-time-matched controls. The outcomes of this study demonstrate that MDCT-derived finite element analysis parameters and texture features, averaged from L1 - L3, showed only a moderate, but no statistically significant improvement of incident vertebral fracture prediction beyond bone mineral density, supporting the hypothesis that vertebral-specific parameters may be superior for fracture risk assessment.