Cheng J, Wei J, Tong T, et al. - In colorectal liver metastases (CRLMs), histopathologic growth patterns (HGPs) were investigated with a noninvasive radiomics model. Researchers performed a retrospective study including patients with chemotherapy-naive CRLMs who underwent abdominal contrast-enhanced multidetector CT (MDCT) followed by partial hepatectomy between January 2007 and January 2019 from two institutions. They reviewed hematoxylin- and eosin-stained histopathologic sections of CRLMs, with HGPs defined according to international consensus. Based on patients’ sources, division of lesions into training and validation datasets was done. To extract radiomic features, pre- and post-contrast (arterial and portal venous) phase MDCT images were used, with review focusing on the segmented tumor–liver interface zones of CRLMs. Assessment of a total of 126 CRLMs with histopathologic-demonstrated desmoplastic (n = 68) or replacement (n = 58) HGPs was done. In distinguishing between replacement and desmoplastic HGPs, the best predictive performance was achieved with the 3 phases fused radiomics signature. Good discrimination was noted with the clinical-radiomics combined model (C-indices of 0.941 and 0.833 in the training and external validation cohorts, respectively).