Seners P, Ben Hassen W, Lapergue B, et al. - In patients with minor stroke and large vessel occlusion (LVO), researchers developed and validated an easily applicable predictive score of early neurological deterioration of ischemic origin (END _i ) following intravenous thrombolysis (IVT) in this multicentric retrospective cohort. The sample consisted of 729 consecutive patients with minor stroke (National Institutes of Health Stroke Scale [NIHSS] score of 5 or less) and LVO (basilar artery, internal carotid artery, first [M1] or second [M2] segment of middle cerebral artery) intended for IVT alone in 45 French stroke centers, including those who eventually received rescue thrombectomy because of END _i. In patients with IVT-treated minor strokes and LVO, END _i can be accurately predicted, which may aid in the selection of the best candidates for direct transfer for additional thrombectomy.