Ho-Le TP, et al. - The association between an osteogenomic profile and rate of longitudinal bone loss (ΔBMD) was defined considering the significance of ΔBMD as a risk factor for fracture. Researchers created the osteogenomic profile from 62 BMD-associated Single-nucleotide polymorphisms from genome-wide association studies (GWAS) that were genotyped in 1384 elderly men and women aged 60+ years. Observations revealed a modest association of the osteogenomic profile, constructed from BMD-associated genetic variants, with long-term changes in femoral neck BMD in women, but not in men.