Prediction of cardiovascular disease among hematopoietic cell transplantation survivors
Blood Advances Jul 29, 2018
Armenian SH, et al. - In order to develop a hematopoietic cell transplantation (HCT)-specific cardiovascular disease (CVD) risk prediction model for facilitating early screening and prevention, researchers studied patients who underwent HCT at City of Hope (COH) and survived 1-year free of clinically evident CVD (N=1,828) for development of heart failure or coronary artery disease by 10-years from index date (1 year from HCT). They developed risk prediction models using COH-derived integer risk scores (based on selected variables including age, anthracycline dose, chest radiation, hypertension, diabetes, smoking). In this study, they recognized distinct groups of HCT survivors at low, intermediate, and high risk of developing late-occurring CVD. The prediction model exhibited good discrimination across outcomes and was validated in an external cohort of HCT survivors.
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