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Prediction of biochemical recurrence in prostate cancer patients who underwent prostatectomy using routine clinical prostate multiparametric MRI and Decipher genomic score

Journal of Magnetic Resonance Imaging Oct 11, 2019

Jambor I, Falagario U, Ratnani P, et al. - Researchers undertook this retrospective cohort analysis to assess how well biochemical recurrence (BCR) in patients who underwent robotic-assisted laparoscopic prostatectomy (RALP) could be predicted using a routine clinical prostate multiparametric magnetic resonance imaging (mpMRI) and Decipher genomic classifier score. This study included 91 patients who underwent RALP and had mpMRI prior to RALP. They reported the development of BCR in 48 (53%) patients. RALP Gleason Grade Group [GGG], MRI-lesion-percentage followed by biopsy GGG, and Decipher score, were identified as the best-performing individual characteristics with tournament leave-pair-out cross-validation (TLPOCV) AUC of 0.73. Feature selection of Decipher+Surgery and MRI + Surgery variables provided the best performance, with TLPOCV AUC of 0.82 and 0.81, respectively. Experts concluded the non-superiority of relative lesion volume measured on a routine clinical mpMRI over Decipher score in terms of performance for BCR prediction.
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