Yu JH, et al. - Through a database of 1,242 consecutive treatment-naive chronic hepatitis B (CHB) patients, the contributors intended to develop a simple and reliable predictive model for hepatocellular carcinoma (HCC) risk in CHB patients receiving entecavir (ETV) / tenofovir disoproxil fumarate (TDF). Four factors associated with HCC, namely, age, albumin, sex, and liver cirrhosis (AASL-HCC) were identified. In treatment-naive CHB patients receiving ETV/TDF, the simplicity and reliability of the AASL-HCC model for HCC risk prediction and its easy applicability in the clinical setting were noticed.