Prediction and prognostic significance of BCAR3 expression in patients with multiple myeloma
Journal of Translational Medicine Dec 22, 2018
Zhang W, et al. - In this investigation, researchers intended to determine if there is an association between Breast Cancer Antiestrogen Resistance 3 (BCAR3), a protein-coding gene that is associated with many tumors, and multiple myeloma (MM). One thousand, eight hundred seventy-eight MM patients (1930 samples) from 7 independent datasets were analyzed. According to the findings obtained, the BCAR3 expression showed a decreasing trend in stages I, II and III. They found that a high level of BCAR3 expression predicts a better prognosis of MM patients and low expression of BCAR3 at diagnosis can predict early relapse. For MM, BCAR3 is an independent prognostic factor. Overall, findings suggested that BCAR3 can be used as a potential biomarker.
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