Burton CL, et al. - A retrospective cohort study was performed to examine the value of candidate prognostic factors (PFs) in predicting carpal tunnel release surgery. Between 1989 and 2013 patients ≥18 years presenting with an incident episode of carpal tunnel syndrome (CTS) were identified. The study findings suggested that patients who are older and who have comorbidities including other pain conditions are more likely to have surgery. On the other hand, patients presenting with CTS during or within a year of pregnancy are less likely to have surgery. This data can advise clinicians and patients about the likely outcome of treatment and to be aware of which patients might be less responsive to primary care interventions.