Khorrami M, et al. - Researchers investigated the value of computed tomography (CT) derived intratumoral and peritumoral texture and nodule shape features in predicting major pathological response (MPR). They defined MPR as ≤10% of residual viable tumor, assessed at the time of surgery. They randomly divided 90 patients with stage III non-small cell lung cancer treated with chemoradiation prior to surgical resection into two equal sets, one for training and one for independent testing. Predictors of MPR comprised 13 stable and predictive intratumoral and peritumoral radiomic texture features. Furthermore, they identified a significant association of radiomic signature with OS and DFS in the testing set. Findings thereby suggest an association of texture features extracted within and around the lung tumor on CT images with the likelihood of MPR, OS and DFS to chemoradiation.