Yoon HJ, et al. - In 83 patients with locally advanced breast cancer (LABC) who finished neo-adjuvant chemotherapy (NAC) and curative surgery, researchers evaluated the prognostic ability of tumor heterogeneity assessed with textural analysis through F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and diffusion-weighted imaging (DWI). Multivariable analysis revealed the independent predictive value for pathologic response seen with number nonuniformity of PET extracted from the neighboring gray-level dependence matrix. For NAC response prediction in LABC, tumor texture indices were noted to be useful. Furthermore, from PET extracted from intensity size-zone matrix (ISZM), high-intensity zone emphasis (HIZE) and high-intensity short-zone emphasis (HISZE) were noted to be significant textural predictors.