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Predicting intestinal recovery after necrotizing enterocolitis in preterm infants

Pediatric Research Nov 03, 2019

Kuik SJ, et al. - Due to the difficulty of predicting intestinal recovery after NEC in individuals, researchers ascertained if several biomarkers predict intestinal recovery in preterm infants after NEC. They analyzed intestinal tissue oxygen saturation (rintSO2) and obtained urinary intestinal-fatty acid binding protein (I-FABPu) levels 0–24 h and 24–48 h after NEC onset, and before and after the first re-feed. Intestinal recovery was assessed in two ways: time to full enteral feeding (FEFt; below or equal/above group’s median) and development of post-NEC complications (recurrent NEC/post-NEC stricture). Twenty-seven preterm infants who survived NEC (Bell’s stage ≥ 2) were included. Data reported that median FEFt was 14 [IQR: 12–23] days. Findings suggested that the rintSO2, its range, and I-FABPu after the first re-feed after NEC anticipated intestinal recovery. When individualizing feeding regimens after NEC, these biomarkers have potential value.
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