Bloom JB, et al. - In men with prostate cancer, authors ascertained the prognostic implications of negative multi-parametric magnetic resonance imaging (mpMRI)-transrectal ultrasound (TRUS) guided fusion biopsy (FB) involving extended sextant, systematic biopsy (SB) plus mpMRI-guided targeted biopsy of suspicious MRI lesions. A favorable prognosis for Gleason Grade Group progression was conferred by a negative confirmatory FB. While counseling patients about the risk of progression and planning future follow-up and biopsies for patients on active surveillance, these results could be used.