Lin CY, Xie J, Freedman SB, et al. - Researchers conducted the study for evaluating the performance of a hemolytic uremic syndrome (HUS) severity score among children with Shiga toxin-producing Escherichia coli (STEC) infections and HUS by stratifying them according to their risk of adverse events. Between 2011 and 2015, medical records of children < 18 years old infected with STEC and treated in one of 38 participating EDs in North America were reviewed. Using the first available laboratory results, the HUS severity score [hemoglobin (g/dL) plus two-times serum creatinine (mg/dL)] was calculated. In total, 167 children had HUS, of whom 92.8% (155/167) had relevant data to calculate the score; 60.6% (94/155) experienced a severe adverse event. The HUS severity score was able to discriminate at a statistically acceptable level between high- and low-risk children < 5 years of age with STEC-associated HUS, however, it seems not to provide clinical benefit at a meaningful risk threshold.