Zhang W, Wang J, Gao J, et al. - In this epidemiologic study, researchers examined how dietary and urinary isoflavonoids are associated with risk of liver cancer in humans. They conducted a nested case-control study, including 217 incident cases of liver cancer and 427 individually matched control individuals, in Shanghai, China. In this study for the first time, a possible correlation of urinary excretion of genistein with reduced risk of liver cancer in women was identified. For liver cancer in women, the adjusted ORs (95% CIs) across increasing quartiles of urinary genistein levels were 1.00 (reference), 0.55 (95% CI, 0.22–1.36), 0.57 (95% CI, 0.23–1.43), and 0.19 (95% CI, 0.06–0.59), respectively, and in men, were 1.00 (reference), 1.22 (0.52–2.86), 1.17(0.47–2.90), and 1.23 (0.55–2.76), respectively.