Prediagnosis weight loss, a stronger factor than BMI, to predict survival in patients with lung cancer
Lung Cancer Dec 11, 2018
Morel H, et al. - Researchers intended to ascertain the recently established link between elevated body mass index (BMI) and improved survival in patients with lung cancer. For this purpose, they analyzed data from the French KBP-2010-CPHG (Collège des Pneumologues des Hôpitaux Généraux (French College of General Hospital Respiratory Physicians)) cohort including a total of 7,051 patients followed up for primary lung cancer diagnosed in 2010 in the Respiratory Medicine Departments of 104 nonacademic hospitals. BMI based stratification was done at diagnosis and to determine the survival, log-rank and a univariate Cox model were used. Findings are suggestive of BMI being an easy but crude assessment tool. Prediagnosis weight loss was identified as a stronger prognostic factor than BMI. Taking into account other variables was nonetheless recommended in order to improve management of patients, and understanding of how prediagnosis body size and nutritional status are associated with cancer survival.
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