Zhao C, Wang S, Pan Y, et al. - Pain on the incision site is prevented by incision-site infiltration with local anesthetics, however, pain relief is limited to the first few postoperative hours. Studies have described better postoperative pain relief with using dexamethasone as an adjuvant to local infiltration; however, this has not been studied in craniotomy patients yet. Researchers conducted a prospective, single-center, blinded, randomized, controlled trial including patients aged between 18 and 64 years, ASA physical status of I–II, scheduled for elective supratentorial tumor craniotomy under general anesthesia. Eligible participants were randomized (1:1) to either the dexamethasone group who received incision-site infiltration of 0.5% ropivacaine plus 0.033% dexamethasone (N = 70) or the control group who received 0.5% ropivacaine alone (N = 70). Outcomes revealed reduction in nearly 27% of opioids consumption and the postoperative pain scores within 72 hours after craniotomy in correlation with adding dexamethasone to pre-emptive incision-site infiltration with the local anesthetic.