Hada M, et al. - In a nested case-control study (157 cases/156 matched controls) within the PLCO Cancer Screening Trial, researchers assessed the link between pre-diagnostic serum levels of 31 arachidonic acid/linoleic acid/alpha-linoleic acid metabolites and ovarian cancer risk using unconditional logistic regression, since inflammation has been suggested to increase ovarian cancer risk and aspirin has been shown to decrease ovarian cancer risk. They found that, there was an increased risk of developing ovarian cancer in the following decade among women with increased levels of five fatty acid metabolites (8-HETE, 12,13-DHOME, 13-HODE, 9-HODE, and 9,12,13-THOME). They also noted that, via metabolism through the LOX/cytochrome P450 pathway, all five metabolites were derived from either arachidonic acid (8-HETE) or linoleic acid (12,13-DHOME, 13-HODE, 9-HODE, 9,12,13-THOME).