Dybjer E, et al. - In this observational study, researchers examined relationships between pre-diabetes/diabetes and cognitive test outcomes, as well as between glucose levels measured during the Oral Glucose Tolerance Test (OGTT) and cognitive outcomes. This investigation included 2,994 people (mean age, 72 years) and was conducted 2007-2012. Pre-diabetic and diabetic persons were found to have minor deficits in global cognitive function, processing speed, and executive functioning. A continuous inverse correlation was observed between glucose levels and cognitive test results and also for participants with no diabetes. This study also revealed stronger associations in older and less physically active individuals. In the pathway between diabetes and cognitive dysfunction, cardiovascular factors were supported as important mediating factors.