Tsubota S, et al. – A research had been designed to detect if PRC2–mediated transcriptomic alterations at the embryonic stage governed tumorigenesis and clinical outcome in MYCN–driven neuroblastoma. Data depicted a strong correlation among expression of MYC and PRC2 target genes, and they predicted survival outcomes. These outcomes suggested that in the development and clinical outcome of neuroblastoma, PRC2–mediated transcriptional control during embryogenesis was a critical step.