Harmon MBA, et al. - Researchers undertook a substudy of the TTM-trial to describe practice of mechanical ventilation and its relation with outcome. In addition, they determined the effects of different target temperatures strategies (33°C vs 36°C) on mechanical ventilation settings. Unconscious survivors of a cardiac arrest due to a cardiac cause were randomized to two TTM strategies, 33°C (TTM33) and 36°C (TTM36). Protective ventilation settings were applied in the majority of the cardiac arrest patients, including low tidal volumes and driving pressures. Association of high respiratory rate with mortality was observed. Compared to TTTM36, TTM33 was noted to result in lower end-tidal CO₂ levels and a higher alveolar dead space fraction.