Farhangi MA, et al. - Researchers gauged the impact of powdered Nigella sativa on serum lipids, glucose homeostasis and anthropometric variables in patients with Hashimoto’s thyroiditis aged between 22 and 50 years old compared to placebo. A substantial reduction was achieved in the body weight and body mass index (BMI) due to Nigella sativa. An improvement was also noted in the serum lipid profile and anthropometric features in patients with Hashimoto’s thyroiditis. Owing to the potential beneficial effects of powdered black cumin seeds, this medicinal plant could be regarded as a beneficial herbal supplement along with the disease-specific medications such as Levothyroxine in order to manage Hashimoto’s thyroiditis-related metabolic abnormalities.

Methods

• The recruitment consisted of 40 subjects with Hashimoto’s thyroiditis, aged between 22 and 50 years old.
• Enrollees were randomly allocated into 2 groups of intervention and control receiving powdered Nigella sativa or placebo daily for 8 weeks.
• An estimation was conducted of serum lipids, glucose homeostasis and anthropometric variables at baseline and after intervention.

Results

• A marked reduction was achieved in the body weight and body mass index (BMI) through Nigella sativa therapy.
• Additionally, a decrease was reported in the serum concentrations of low density lipoprotein cholesterol (LDL) and triglyceride (TG) in Nigella sativa-treated group after 8 weeks.
• Data disclosed a substantial increase in the serum high density lipoprotein cholesterol (HDL) following treatment with Nigella sativa (P < 0.05).
• The placebo treated group did not display any of these changes.
• An inverse link was demonstrated between serum Nesfatin-1 concentrations with serum triglyceride (TG) (r = -0.31, P=0.04).