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Potential risk factors for celiac disease in childhood: A case-control epidemiological survey

Clinical and Experimental Gastroenterology Jul 08, 2019

Bittker SS, et al. - Researchers intended to determine if there is an association between 9 variables (incidence of ear infection before 2 years old, courses of antibiotics before 2 years old, duration of breastfeeding, vitamin D drop exposure in infancy, vitamin D supplement exposure between 2–3 years old, age at gluten introduction into the diet, fat content of cow’s milk consumed between 2–3 years old, quantity of cow’s milk consumed between 2–3 years old, and type of water consumed at 2 years old) and celiac disease (CD) in children. An online survey was performed among families residing in the United States with at least one biological child between the ages of 3 and 12. After exclusions, 332 responses associated with CD (cases) children and 241 responses associated with children without CD (controls) remained. This research is the first to discover a link between the consumption of skim milk and the use of CD and vitamin D drop over 3 months and CD. It also provides proof that CD is connected with early-life exposure to antibiotics and early-life infection, particularly ear infection.
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