He C, et al. - Researchers used the Kentucky Cancer Registry to assess five key proteins involved in various cancer-related pathways as well as their association with breast cancer recurrence. A total of 475 retrospectively identified primary invasive breast cancer cases that were diagnosed and treated at University of Kentucky Medical Center between 2000 and 2007, were included. According to findings, differential associations of the expression/activity level of various proteins with risk of recurrence of breast tumor subtypes were observed. Among ER+/PR+/HER2− patients, a decreased risk of recurrence was observed in relation to higher ABL1/ABL2 activity in primary tumors. Irrespective of the subtype, a remarkably increased ABL1/ABL2 activity was seen in recurrent tumors vs matched primary tumors among patients with recurrence.