Ried K, et al. – The goal of this study was to describe biologically plausible mechanisms of garlic's blood pressure (BP)–lowering impact. Data reported a stimulating impact of garlic–derived polysulfides on the production of the vascular gasotransmitter hydrogen sulfide (H₂S), with enhancing the regulation of endothelial nitric oxide (NO), resulting in smooth muscle cell relaxation, vasodilation, and BP reduction. Furthermore, data was indicative of a possible role of sulfur deficiency in the etiology of hypertension and plausible alleviation with supplementation of organosulfur compounds derived from garlic.