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Potential metabolic markers in glaucoma and their regulation in response to hypoxia

Acta Ophthalmologica Feb 01, 2019

Vohra R, et al. - Investigators assessed 12 candidates with normal-tension glaucoma (NTG) and 11 as a cohort to evaluate the novel diversity in serum levels of glucose, lactate and amino acids among the 2 groups, at baseline and in response to universal hypoxia. They observed a comparative decline in baseline levels of lactate and total amino acids among NTG candidates. They noticed an incline in lactate levels among NTG cases but remained stable during hypoxia in the control group. Total amino acid levels were reduced in the control group whereas no changes were obtained in subjects with NTG during the recovery phase. Overall, they found reduced serum levels of lactate and total amino acids as potential markers for NTG.
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