Zhou N, Li C, Zhou Y, et al. - In this quantitative proteomics analysis, researchers investigated the protein content in serum exosomes (SEs) from oral squamous cell carcinoma (OSCC) patients with lymph node metastasis (LNM), OSCC patients with no LNM, and healthy controls. By bioinformatics, they analyzed differentially expressed proteins (DEPs). They evaluated the correlations between the DEPs expression and clinicopathologic factors. Overall 415 proteins were found. In the SEs of OSCC-LNM, the upregulation of 37 proteins and downregulation of 28 proteins was identified, compared with controls. In this study, a possible association was suggested between PF4V1, CXCL7, F13A1 and ApoA1 from SEs and metastasis of OSCC, which would aid the diagnosis of OSCC-LNM.