Matrone A, Ceccarini G, Beghini M, et al. - One thousand fifty-eight consecutive differentiated thyroid cancer (DTC) individuals treated with total thyroidectomy and registered at the time of the first ¹³¹I treatment were assessed in order to explore the connection between BMI, DTC aggressiveness at the diagnosis and clinical result. Based on their BMI, study participants were divided into four groups: underweight (< 18.5 kg/m²), normal weight (18.5-24.9 kg/m²), overweight (25-29.9 kg/m²) and obese (≥ 30 kg/m²). According to results, no link was found between BMI and DTC aggressiveness in the study group of Caucasian individuals, either at the time of diagnosis or during follow-up. Such findings suggest that postsurgical evaluation and therapeutic attitude for treatment and follow-up of DTC should be based on the risk class applied to the general population, with no concern for BMI.