Chen JR, Huang MS, Lee YC, et al. - In lung cancer patients, poor disease-free survival (DFS) and overall survival (OS) were observed in relation to HTR3C (a member of 5-HT ₃ receptor family) expression levels, suggesting the usefulness of HTR3C as a predictive biomarker for lung cancer.

• The association between the HTR3 family of 5-HT receptors (HTRs) and lung cancer patients’ survival was assessed via Kaplan–Meier analyses, and expression levels of target proteins were evaluated via immunohistochemistry.

• In lung cancer patients, amplification of HTR3C with high frequency was evident, and there was a significant association of HTR3C protein expression levels with lymph node metastasis as well as with distant metastasis in lung cancer tissues.

• The high-level HTR3C expression group had a decrease in DFS and OS rates vs the low-level HTR3C expression group.

• HTR3C expression was identified as a significant predictor of patient outcomes.