L'Huillier AG, et al. - Biopsy-proven cases of posttransplant lymphoproliferative disorder (PTLD) among children during a 15-year period were identified in a hospital-based registry in addition to reviewing the trends in PTLD rates, the sites of involvement, and the associated survival rates. Researchers studied eighty-two patients with first-episode PTLD with a median age of 6.4 years at diagnosis. PTLD most frequently occurred at tonsillar/adenoidal (T/A [34%]) and gastrointestinal (32%) sites, followed by miscellaneous (defined as less common sites including central nervous system, kidney, lung, and soft tissue [12%]), lymph node (11%), and multisite (11%). They noted a survival advantage in correlation to T/A PTLD than PTLD at other sites, even after adjustment for potential confounders. Clinical categorization of PTLD according to anatomical site of occurrence is proposed in this work based on the observations.