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Postoperative opioid‐related adverse events with intravenous oxycodone compared with morphine: A randomized controlled trial

Acta Anaesthesiologica Scandinavica Aug 17, 2020

Cuvillon P, Alonso S, L’Hermite J, et al. - Researchers compared opioid‐related adverse events (ORAES) of intravenous oxycodone and morphine following total hip arthroplasty. They assessed the number of patients who developed ≥ 1 ORAEs (nausea, vomiting, respiratory depression, pruritus, urinary retention requiring evacuation, allergy, hallucinations) within the first 24 hours (primary outcome). They also evaluated pain scores and opioid consumption (secondary outcomes). This analysis involved 238 patients having similar characteristics. Findings revealed that within the first 24 hours, no significant attenuation in ORAEs was brought about by IV oxycodone vs similar ratio of IV morphine.

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