Darlix A, et al. - Given that foci of malignant glioma can be found within diffuse low-grade gliomas (DLGG) samples obtained from surgical resections, researchers conducted this single-center retrospective study to ascertain if postponing the medical treatment in selected patients is feasible. The sample consisted of a consecutive series of DLGG managed with this conservative strategy. Inclusion criteria included at least 1 focus of malignant tumor (grade III–IV, WHO 2016), no prior chemotherapy or radiotherapy, no less than a subtotal resection of the fluid-attenuated inversion recovery tumor volume, no intention to treat with immediate adjuvant therapy, and a minimum of 2 years of follow-up. Forty-four patients met the criteria for inclusion (median age 36, median time interval from diagnosis 7 months). In selected patients, postponement of the medical treatment in DLGG with malignant tumor foci following total or subtotal resection should be considered. The majority of surviving patients were still professionally active, with no seizures.