Choudry MHA, et al. - Researchers investigated the influence of postoperative complications following cytoreductive surgery–hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC) on perioperative and oncologic outcomes. In addition, they compared the Comprehensive Comorbidity Index (CCI) with the traditional Clavien–Dindo classification (CDC) in terms of predicting these outcomes. On analyzing a prospective database of 1,296 patients with peritoneal metastases (PM) undergoing CRS-HIPEC between 2001 and 2016, they emphasized reducing postoperative complications after CRS-HIPEC for optimal short- and long-term outcomes. For 24% of the patients, major postoperative in-hospital complications were seen. Compared to CDC, CCI proved superior and more sensitive for assessing surgery- and cancer-related outcomes after CRS-HIPEC. Postoperative in-hospital complications (measured by CDC or CCI) were independent prognosticators for 30-day post-discharge morbidity and readmission, as well as for survival, in the multivariate Cox proportional hazards models.