Borgen TT, Bjørnerem A, Solberg LB, et al. - In this cross-sectional study, researchers examined the risk factors for fractures including BMD, trabecular bone score (TBS), and proportion of vertebral fracture using vertebral fracture assessment (VFA) in patients with different types of fragility fractures, and analyzed the differences between central (vertebral, hip, proximal humerus, pelvis) and peripheral (forearm, ankle, other) fractures, after adjustment for sex, age, BMI, and BMD. Compared with patients with peripheral fractures, those with central fragility fractures showed lower femoral neck BMD, lower TBS, and higher prevalence of vertebral fractures on VFA. This indicates that patients with central fragility fractures show a more severe deterioration of the bone structure, which translates into a higher risk of subsequent fractures of fragility and should, therefore, be given the highest priority in the prevention of secondary fractures, although attention to peripheral fractures should not be reduced.