Inciarte A, Leal L, Masfarre L, et al. - Researchers performed a retrospective, longitudinal, observational study in sexual assault (SA) victims who attended the Hospital Clinic in Barcelona from 2006 to 2015 in order to investigate the feasibility of administring postexposure prophylaxis (PEP) after a SA. Among a total of 1,695 SA victims attending the emergency room (ER), 883 met the PEP criteria [median age: 25 years (IQR:21–33 years); 93% female]. From exposure to the presentation at the ER, the median interval of 13 h (IQR 6–24 h) was reported. Appreciable level of risk was noticed in 47% (n = 466) of individuals. The SA victims, however, had poor follow-up and compliance rates. In addition, adverse events occurred in > 50% of the patients, which were the main reason for PEP interruption. They emphasize investigating strategies to increase follow-up testing and new better-tolerated drug regimens to address these issues.