Ruggeri A, et al. - Post-transplant cyclophosphamide (PT-Cy) was assessed as graft-versus-host disease (GVHD) prophylaxis post-stem cell transplantation (HSCT) from matched sibling donors (MSD) and unrelated donors (UD) transplants. An enhancement was noted in the impact of PT-Cy, when it was given in combination with immunosuppressive (IS) drugs, as a GVHD prophylaxis in MSD and UD HSCT. Moreover, the addition of IS drugs to PT-Cy attenuated the risk of severe chronic GVHD, reducing mortality and improving survival.