Forker CM, et al. - Patients enrolled in the Lung Transplant Outcomes Group prospective cohort study at the University of Pennsylvania during two eras [2004-06 (n=61) and 2013-15 (n=67)] were examined to assess if 6-hour post-reperfusion plasma levels of soluble thrombomodulin (sTM), protein C, and plasminogen activator inhibitor-1 (PAI-1) are associated with post-transplant acute kidney injury (AKI) severity. In 57 (45%) patients, AKI was reported across both eras: 28 (22%) stage 1, 29 (23%) stage 2-3. In each era, AKI stage was correlated with higher sTM and lower protein C plasma levels.