Bundhun PK, et al. - Prasugrel vs clopidogrel-induced outcomes following percutaneous coronary intervention (PCI) were directly compared using data from relevant publications retrieved from the Cochrane library, EMBASE, MEDLINE and Google scholar. Adverse cardiovascular outcomes were the primary endpoints, and bleeding events were the secondary outcomes. This analysis was conducted via RevMan 5.3, whereby odds ratios and 95% confidence intervals were considered statistical parameters. In patients who underwent PCI, the use of prasugrel vs clopidogrel resulted in significantly lower adverse cardiovascular outcomes. Furthermore, no significant difference was noted in terms of Thrombolysis in Myocardial Infarction defined major and minor bleeding, indicating prasugrel was well-tolerated following, PCI especially in patients with acute coronary syndrome.