Simpson RE, et al. - Researchers assessed all pancreatoduodenectomies (PD) performed from 1/2013-12/2017 to assess the outcomes of epidural analgesia (EDA) use for pain control post-pancreatoduodenectomy. This is the largest single-institution series comprising 671 consecutive PD (429 EDA, 242 non-EDA). EDA patients were noted to experience significantly less wound disruption (0.2% vs 2.1%), unplanned intubation (3.0% vs 7.9%), pulmonary embolism (0.5% vs 2.5%), mechanical-ventilation >48hrs (2.1% vs 7.9%), septic shock (2.6% vs 5.8%), and lower pain scores. They observed no differences in cardiac or renal complications; pancreatic fistula (B+C) or delayed gastric emptying; 30/90-day mortality; length of stay, readmission, discharge destination, or unplanned reoperation. The data thereby provide support to the use of EDA for optimization of pain control.