Demirler B, Krug KB, Burke C, et al. - This study attempted to explore if their biological relevance can be estimated using spectral CT-datasets. Between 07/2017 and 06/2019, patients with breast masses visualized on spectral CT-examinations were included in this bicentric retrospective study. Via two independent readers, conventional CT-images, iodine density-maps, virtual monoenergetic-images (40 keV, 100 keV) and Zeffective-maps were assessed. The study enrolled a total of 106 breast masses (malignant/benign: 81/25, 76.4%/23.6%). The primary outcomes imply that spectral CT-datasets might allow us to estimate the biological dignity of breast masses detected on clinically indicated chest-examinations.